At least two people have been killed after shots were fired at Central Michigan University, according to Michigan State Police.
Local authorities said the suspect is still at large and have urged everyone on campus - which is located in Mount Pleasant - to take shelter.
The shots were reported to have occurred on the fourth floor of Campbell Hall, reports Independent UK.
A tweet from the official Twitter account for City of Mount Pleasant said the suspect was considered "armed and dangerous". He is said to be wearing mustard yellow jeans and a blue hoodie.
The Mount Pleasant police and Isabella County Sheriff's Department are assisting university police, officials said.
All the schools in the Mount Pleasant have been put on lockdown, as has the university campus.
The university, which has about 20,000 students, is in Mount Pleasant, about two hours northwest of Detroit.