Zimbabwe's Vice-President Emmerson Mnangagwa has been removed from his post, the country's government has announced.
Mr Mnangagwa, 75, had displayed "traits of disloyalty", Information Minister Simon Khaya Moyo said.
His removal makes it more likely that President Robert Mugabe's wife Grace will follow in her husband's footsteps as leader of Zimbabwe, according to a BBC report.
She had earlier called on her husband to remove his vice-president.
"Mr Mnangagwa's conduct in discharge of his duties is inconsistent with the responsibilities," the information minister said.
"The vice-president has exhibited traits of disloyalty."
Mr Mnangagwa, a former intelligence chief, had been a leading candidate to succeed President Mugabe, 93.
His sacking means Grace Mugabe is expected to be appointed vice-president at a special congress of the ruling Zanu-PF party next month.
Mrs Mugabe had earlier called for the party to expel Mr Mnangagwa, according to the state-run Herald newspaper.
Addressing members of indigenous church groups at a rally in the capital, Harare, on Sunday, Mrs Mugabe said, "The snake must be hit on the head."
"We must deal with the real snake behind the factions and discord in the party. We are going for the congress as a united party."
Last month, she warned of plans to stage a coup, hinting that supporters of Mr Mnangagwa were behind the alleged plot.
