Theresa May is to reshuffle her cabinet today (Monday), with a number of new faces expected to join her top team.
No 10 has described reports Education Secretary Justine Greening and Health Secretary Jeremy Hunt will be among those moved as "all guesswork".
Philip Hammond, Boris Johnson, Amber Rudd, and David Davis are among key figures expected to stay in place, according to a BBC report.
Labour said Mrs May should focus on the pressures in the National Health Service (NHS) rather than what it said was a "desperate PR exercise".
Other current ministers reported to be vulnerable include Leader of the House of Commons Andrea Leadsom, Business Secretary Greg Clark, and party chairman Patrick McLoughlin.
The reshuffle, which will continue into Tuesday, is being seen as an opportunity for Mrs May to promote more women, with female ministers only currently making up six of the 23 full members of her top team.
She is also under pressure to preserve the balance between Brexit sceptics and enthusiasts, while showing the government has a purpose beyond leaving the EU, which critics say is monopolising ministers' time.
The changes, which will be Mrs May's third reshuffle since becoming PM in July 2016, were triggered by her sacking of Damian Green last month as first secretary of state.