Japanese shares edged down on Monday after index-heavy stocks such as SoftBank and Terumo lost ground, offsetting gains in financial stocks, which rallied after US yields rose.
The Nikkei fell 0.2 per cent to 22,114.03 in midmorning trade.
Medical equipment maker Terumo Corp stumbled 3.4 per cent and SoftBank shed 1.0 per cent, collectively knocking 25 points off the Nikkei, reports Reuters.
Murata Manufacturing and TDK Corp both dropped 1.3 per cent.
Financial stocks outperformed following a rise in US yields with insurers T&D Holdings up 6 per cent, Dai-ichi Life surging 4.3 per cent and Mitsubishi UFJ Financial Group 2.1 per cent higher.
The broader Topix rose 0.1 per cent to 1,753.44.