The Sevilla crowd was ready to erupt when forward Luis Muriel appeared free from markers inside the area, with the ball in perfect position for his header just a few meters (yards) from the goal, reports AP.
De Gea came up with a spectacular one-handed reflex stop, quickly stretching out his right arm to parry the ball over the crossbar and stun both Muriel and the local fans.
It was the highlight of another solid performance by De Gea, and it helped United hold Sevilla to a 0-0 draw in their first-leg match in the last 16 of the Champions League on Wednesday.
In the night's other game, Shakhtar Donetsk came from a goal down to beat Roma 2-1 after midfielder Fred netted the winner with a perfect free kick in the 71st minute.